Promethazine and codeine should be used in the course of pregnancy provided that the likely benefit justifies the prospective risk to your fetus.
The subsequent laboratory checks might be impacted in sufferers who are receiving therapy with promethazine hydrochloride.
Anaphylactic reactions, as adjunctive therapy to epinephrine and other common measures, once the acute manifestations happen to be managed.
The next serious adverse reactions are described, or described in bigger depth, in other sections:
The mixture of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric clients fewer than 6 yrs of age. Concomitant administration of promethazine products with other respiratory depressants has an Affiliation with respiratory melancholy, and at times death, in pediatric clients.
For prescriptions where a measuring system just isn't offered, a pharmacist can provide an ideal calibrated measuring product and can provide Guidelines for measuring the correct dose.
If this SPL contains inactivated NDCs listed through the FDA initiated compliance motion, they will be specified as such.
Nursing mothers using codeine can also have higher morphine stages of their breast milk If they're extremely-immediate metabolizers. These better levels of morphine in breast milk may well produce existence-threatening or deadly Unwanted side effects in nursing toddlers. Instruct nursing moms to Look ahead to signs of morphine toxicity within their infants such as improved sleepiness (over common), problem breastfeeding, respiration problems, or limpness.
Promethazine HCl Oral Resolution may possibly reduced seizure threshold. It should be used with caution in folks with seizure Issues or in individuals who will be applying concomitant remedies, for instance narcotics or community anesthetics, which can also influence seizure threshold.
Promethazine HCl occurs as a white to faint yellow, basically odorless, crystalline powder which bit by bit oxidizes and turns blue on prolonged publicity to air. It truly is freely soluble in water and soluble in Liquor.
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Neuroleptic malignant syndrome (NMS) which can result in Dying. Inform you Health care provider right away In case you have any of the next signs and symptoms of NMS:
Make use of other supportive measures (like oxygen and vasopressors) from the management of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias will require State-of-the-art life-support tactics. Gastric emptying might be helpful in removing unabsorbed drug.
Promethazine HCl could be employed alone or being an adjunct to narcotic analgesics all through labor (see DOSAGE AND ADMINISTRATION). Minimal facts propose that use of Promethazine throughout labor and supply doesn't have an appreciable impact on the length of labor get more info or delivery and would not improve the hazard of will need for intervention inside the new child.